Boro's Emirates FA Cup fifth round tie against Tottenham Hotspur will be a 7.55pm kick-off on Tuesday 1 March.
The match at the Riverside will be broadcast live on BBC One.
Boro have beaten Mansfield Town and Manchester United on the road en route to the fifth round, while Spurs saw off Morecambe and Brighton and Hove Albion on home turf.
The sides last met in the same competition two years ago, with Boro earning a 1-1 draw against their Premier League opponents and a replay at the Tottenham Hotspur Stadium - but this time around, extra time and penalties would follow should the sides be level after 90 minutes.
Ticket information will be confirmed in due course via mfc.co.uk. Please do not contact the Ticket Office until selling arrangements have been publicised.